Not familiar with those; could you provide a summary as it pertains to this topic?
Permutation City is a novel about, among other things, being able to upload human personalities and edit them, so that people can, at a drop of a hat, pick something to be obsessively interested in and make themselves be so. I don't want to spoiler it too much, but it examines the consequences of this in a really impressive way.
Diaspora is a sort of related book which does some similar things. It opens with an amazing section called "Orphanogenesis" which starts off as a highly technical discussion of how one builds a new sentience out of software, and ends up in first-person POV of the sentience that has been built, and does, IMO, a smooth gradual transition between them.
Blindsight's narrator is a human who because of radical brain surgery has lost the capacity for empathy entirely, and who has hence had to develop the facility to intellectually deduce what's going on in other people's heads to an extreme degree; because of this, he is assigned to a crew of even weirder and more alien people going out to make contact with aliens, as an interpreter to translate their thoughts and insights for the folks back home. I suppose one could just about force a story like that into mainstream, or at least as much embedded in a realistic world as, say,
Arkham Asylum, except for the bit with the aliens. But it would be a real push, and neither of the others seem to me to be doable in mimetic fiction at all. Also there are some of Egan's short stories that do similar things, such as "Learning To Be Me", in which the narrator is having his mind recorded for long-term storage, and has a philosophical crisis as to whether he is really the copy of him running on his brain, which is mortal and going to die, or the copy running on the recorder which is less so, and whether there is any way of telling the difference.