Well, start by just optimizing the skill shuffle.
High resources/contacts/social skills in human form, high physical skills in wolf form, he's good at both sides of being a werewolf.
Give him a few more skill points to play with than is typical for your refresh level, or simulate the extra experience with stunts that improve skills or swap trappings so he's solidly good at whatever you want him to be, and unusually expert at his specialties.
add the usual inhuman speed/strength/teeth. Give supernatural recovery NOT as part of his shapeshift, he can heal himself in human form too, and heal either form incredibly fast. Don't forget your echoes of the beast and pack instincts stuff. Maybe give him a pack of wolves to work with in wolf form, and an organization of some kind in human form (mercenaries, criminal organization, corporation, something). Alternately give him a pack of lesser werewolves to lead, built along similar lines but with fewer skills/refresh. Pack instincts is really scary with a big pack. If you want a hybrid human/beast form option consider human guise instead of human form...you get most of the shapeshift powers if you go all furry but don't get skill swap unless you change to a true animal.
I think that's probably enough to pull off a pretty impressive character. If you really want to go gonzo on the SU powers, some kind of psychic attack (incite emotions or maybe dominate) that lets him exert power over wolves and the "wolf" portion of opposition (easier if a werewolf, but some aspects might let him into other characters) might be possible, but I'd just use social skills myself.