Zone definitions are left to the GM. If the GM says the zone is big enough to fit 200 fighting vamps, then it is. And if so, the 200 vamps would be able to punch each other freely ... or punch the non-vamp in the middle. And conversely, the non-vamp in the middle could use a zone attack on all of them, too.
That said, I think that the combat would work a lot better if things were more spread out, zone-wise. While half a parking lot might be a reasonable zone some times, perhaps the lot needs to be divided down into smaller sections to handle a horde of vamps attacking. If you need justification, perhaps a knot of ten or so vamps constitutes enough of an impediment to movement that it creates it's own boundary?
Note that this wouldn't prevent the vamps from ganging up on the defender. They'd just need to find improvised thrown weapons so that they could attack from the adjacent zones...