There's a big balancing act here. On one hand, you don't want to follow "the formula" and be completely unoriginal. However, you also want to make sure you don't lose structure completely.
A few months ago, I read a book that was an autobiography of a young woman as a private detective, but she tried to structure it as a novel. However, because she was sticking too strictly to the truth of what happened, there was no structure at all. It was just a bunch of stuff that happened to her. There was no story arch, there was a beginning in that she got hired by the detective agency, but beyond that there was nothing. It was interesting, but it felt scattered and very unfulfilling. And this was an autobiography, so I wasn't expecting a story.
It's one thing to throw a monkey wrench into the works and do something insane like killing off who the readers think is the main character on page 120, but try to pick some sort of very basic structure and stick to it at least, whether it's the three acts of a screenplay, the five acts/five parts/two scenes structure of a Shakesperian play...just pick something. Otherwise, there'll be no real feeling of resolution and your readers will be left feeling blah at the end.
The Abstruse One
Darryl Mott Jr.