I used some elements of boss battles from MMOs in a D&D game I ran a few years ago that really went over well with the players and helped even the action advantage of a group of PCs vs One Big Bad. D&D 5e did something right with Lair Actions for their legendary monsters, but what happens if the PCs are not fighting legendary monsters, but simply a named villain? Legendary Monsters often have a Lair that 5e treated as kind of a separate character that could only be defeated when the main monster was defeated (or if you removed the monster from the lair). The Lair always acts on Initiative Count 20, can do one of three different things (usually an attack of some kind, alter the environment in some way, and possibly some kind of a defense). The entire premise is that the lair is under the monster's influence because it's lived there for a long time.

What I ended up doing is giving the named villains two initiative counts and the second initiative count would go away at half hit points. The villain could only either attack or move on it's second initiative count. I usually had them move, which kept the villain from getting boxed in by the players. The villain would change some environmental variable, remove itself from a surround, or use magic to escape to another place. It kept the battles constantly moving and the kept the PCs thinking and engaged.

Now, I'd like to preface my suggestion with the fact that I haven't run or played in DFRPG in a couple of years, so I'm a little rusty on rules. If I were to do something like what I'm suggesting in DFRPG, I would build a custom "Boss" power. It would have it's own stress track and would essentially act like another character in the battle, one that goes off of a set initiative based on the level of "Boss" power that's initially purchased. As the power is used it would tick off a box of stress. Once all the boxes are ticked off, the Boss power would go into hibernation. Before the Boss Power is used up, it would certainly make things very interesting for the PCs and should be enough to make the PCs expend some serious resources. It would, in my opinion, provide for a more epic battle. Minions are also very useful, but sometimes it's even more fitting to have someone who could take on three or four PCs just by himself as a show of power.

If I can find my PDFs, I'll try to write something up just to see what it'll look like.

Next:  something suitable for thread necromancy....

10-shift necromantic flesh-eating ritual

Targeted with a lock of hair, the spell eats your luscious locks and leaves you bald.  You run away in embarrassment.

Next: A Summer Faery hits you with a 12 shift Biomancy evothaum attack

Read some William Gibson:  Neuromancer and the two books that follow (I forget the titles). 

Count Zero and Mona Lisa Overdrive. Both great stories.

As a rambling continuation, the two minis I got were done in the ultra fine plastic. I'm fairly certain the strong plastic is similar to the bonesium or whatever they call it that Reaper did with their Bones line, which I have a lot of lying around. It seems HeroForge sources their stuff from Shapeways, which makes the website a front end with their own designs for a backend printer that's already available to everybody else. Dunno if you're familiar with Shapeways or not, but you can 3D model something with their website and then order 3D prints from them for a price. HeroForge has just simplified it for the model market.

I spent a few minutes building my own Harry Dresden miniature in HeroForge.

Le woot!

I'm also running a game set in the European theatre of World War II. Right now it's confined to a city, but I have grand plans.

It's also a bit difficult to judge their powers and abilities since they can shift from writer to writer, but I would say that as a group they are just as, if not more, capable than the group put together in Skin Game. I would say they could put up a good fight against almost anyone/anything baring Outsiders, the six Queens, and similarly powered people.

It would be fun playing a game where everyone was an anti-hero, I think it's a good idea.

I've never run a true villain game, but I've played games with a few villainous PCs who were part of the main group but had much different agendas with the end goal McGuffin. They ended up playing against each other in subtle ways. At the end of this particular campaign, the villainous PCs ended up getting their way through sheer trickery, a move that cost two PCs their lives. The thing is, the other PCs knew about the different agendas. They just weren't prepared for the Machiavellian scheming.