Two things.
1. I've run several Amber games using the setting based on the novels. I tried talking my players into using the same rules but going with a new setting, but they would never go for it. That setting basically requires that the NPC's from the stories are present, although not necessarily showing up in any scene. The PC's can look them up pretty much at will. I found they were largely archetypal so it was not terribly difficult to portray them. The players who knew the stories were willing to buy into how I ran them and I actually got complimented on doing it well most of the time. I think I largely went with the NPC's having a particular attitude and atmosphere that I tried to portray, one point they wanted to deal with and then let the players direct the conversation afterward.
2. I had it easy in that Amber was setup this way by default but you could readily import this idea into any other game. The powerful NPC's I dealt with were all involved in an intricate and subtle game of chess. Sure the PC's were pawns, but
they were also the only pieces on the board that could afford to move. Everyone else was locked because the moment they began to show their real power, the whole board would light up as everyone else responded. In the Dresden Files novels, Harry only looks awesome because he can move around and is largely free to do things. The White Council, the various vampire factions, the Winter and Summer courts, they're all stuck. They can't move. Hell they have a big pact (the Unseelie Accords) that generally spells that out in big letters. You can either add some adversary for Harry & Friends to stalemate against or you can have them join a faction.
Yes, I know as Harry gets more power in the novels it comes with increasing ties and obligations. It puts him firmly on the board as something other than a pawn. The point remains however: pieces like that in this sort of game can only move freely when the GM/author sets up specific circumstances that allow it. Otherwise the offending piece will be lynched by it's own side with extreme prejudice just to attempt to convince the other factions that the offender was a rogue element.