Thanks so much for your suggestions, folks! It has actually helped me walk through this process, which I was finding a little daunting. I was going to also suggest to my players potentially creating our own little town instead of using New York but it seems that New York got everyone interested.
The different Themes suggested have been very important - there is so much New York can encompass and getting an idea of where you guys have gone before has given me some ideas. Especially the notion of the Rotten (corruption) that can be at the heart of New York. I'm also going to be going with, I believe, something along the lines of the anonymity that New York can bring about and how isolating it can be, as part of an overall thread for what is going on in a number of different parts of the mortal and supernatural community. So I chose LAND OF EIGHT MILLION STORIES as the overall aspect, though I'm still tweeking it. I also LOVE the idea of Cultural Battleground and that gave me an idea for a White Court versus Red Court plot that I'm going to be putting in, so thanks for that one too.
The locations I also divvied out to my players, and they seem to be having fun kicking around their favorite neighborhoods and locations as well. I think that Manhattan is going to stay the focus, primarily though, just to keep this from getting too large. If I can manage to widen things a little more, I will, but I will start with the city.
Oh: And to drop in on the debate about the driving thing? As someone who got stuck in two and a half hour traffic today, I think EPIC LEVEL TRAFFIC might be a better aspect
People definitely drive!
But thanks folks, I really appreciate it.