Oh my gosh... I love the 'Miami Vice Wardens' idea... Smiley
The more I think on it the more I like it too. I am curious about all these ideas though, are you thinking of a Dresden Files games set somewhere in 80s TV Land, or are you more looking for classic 80s shows that have decent campaign structures to mine for ideas for a modern game? Either way that's pretty cool, but it also got me thinking about Dresden Files Miami Vice in two different directions.
First would be the modern setting of two Wardens in Miami holding the front line during the Vampire Wars. (Granted that would have to be a little bit in the past.)
The other would be set in 80s era Miami, again with the two Warden's trying to keep order in a chaotic border city, but the tone, color, setting, and threats would be radically different.