I've played in a number of games, but by far the largest and longest-running is Enduring the Apocalypse. As the name suggests it was originally about PCs trying to survive the gradual end of the world, but the focus has shifted massively over the years.
It started back in 2010. Wasn't my idea, actually; someone wanted to play an ultra-high-Refresh game and I got talked into running it. It was set in Berlin, and the basic concept was that the players were the morally-mixed power players of the city trying to deal with the post-Changes world. The PCs weren't a team, exactly, but the German government's magical intelligence service brought them all together to address imminent crises like an army of demons preparing to descend upon the city.
A lot has happened since then. Many players have left, and none of the original participants are still in the game except me, but the current three PCs have been stable for a long while. I've been using former PCs as villains, and honestly some of them make more sense in that role than they did as protagonists.
We recently finished a major story arc, which was about a G8 meeting where the spooky sides of the world's major governments hashed out an agreement to cooperate. The PCs were involved in the diplomacy, and also carried out a secret mission to decapitate the CIA so that the Library of Congress could take over the American side of things. They were very successful, but the summit ended on a down note as a now-villainous former PC managed to talk the various nations into letting him wriggle out of the consequences of his earlier misdeeds.
Since the game started at 18 Refresh, it naturally tends to go very big. Fight scenes with small armies of participants, people claiming dominion over regions of the Nevernever, weapon 10+ attacks being thrown around left and right, people casting rituals with massive complexity, high-stakes arguments with a whole bunch of independent sides. That kind of thing. The system has held up remarkably well under some pretty intense pressure.
It's not a particularly subtle story, but we've managed some interesting character arcs. One character recently half-died and came back, and is now on the path to picking up a Sword of the Cross after a deathbed conversation with Uriel.
I could go on and on and on, but it's probably better to let you ask if there's anything in particular you want to know.