I am quite tired of the vampire and werewolves (and etc) stories about, oh, having a life and having adventures (with angst/romance/thrills thrown in as appropriate). I know this sounds like it would cover pretty much everything, but I am thinking of a specific type of story. They're all blurring together in my mind...i liked them, but now it feels like the last bit of candy you have as a kid on halloween. You're sick of it. Person is werewolf/vampire. There are downsides, which they complain about, but really, they aren't as bad as they make it seem, because there are a lot of upsides and they go and have adventures, fighting evil/monsters/politics/what have you and getting a love interest.
After all this, I'm in the mood to read about a truly tortured soul (not an angst-ing one), for whom being a werewolf (for example) is actually a curse... all downsides... I guess what I want is a horror story, and not the sort that is about a rampaging monster. The internal horror story, the stories that are about guilt and redemption, of the struggle and triumph (although that does not imply 'happily ever after') against one's own faults, failings, weaknesses and disadvantages.