Yeah but they are pretty close... Can't be ignored that there may be a connection. I'm not saying you could get to the cottage from DR.. But there may still be a connection.
It's not what I imagine, but it's possible.
Personally, I think that the real world places that correspond with the cottage would be hard to get to. Harder than renting a boat, navigating a reef, and resisting an urge to leave.
That's why I suggested Lake Karachay. Just being there is hard to survive, even with the lake filled in with concrete. The Bikini atoll is another possibility, which is both deadly and teeming with life.
Or their links might be only naturally occurring. There are probably places that are abundant with nature, like Madidi National Park, which are suited to MS. And there are places that are deadly to everything, like Lake Nateon, which are suited to MW.