I used to do that all the time. I'd pick up book after book from the TBR pile, and just didn't feel like reading any of them.
I finally realized that I'd kept picking the same books over and over (and overlooking the same ones). So they all felt stale. Since I started a random system for picking books, making sure not to read two similar books in a row, and some goofy TBR challenges (things like "pick a book with gold lettering on the cover") to shake things up a bit, I hardly ever have the readers block anymore.
Ah, yes. Making OCD Work For You. I could write a pamphlet.
Of course, if you don't have a TBR pile, that makes the challenges a little more risky--picking up the first book at the library that you find with a verb in the title might net you something really odd. But then again, that might just be what you need to break out of the readers block.
In another group, we have a quarterly reading challenge, which I've found really helpful for getting out of a reading rut, too. Summer's was a book that won a Pulitzer; Fall's is a banned book.
Mostly, in my experience, anyway, readers block is the result of being in a reading rut, so anything that gets you out of that will help. Non-fiction is good, because it doesn't feel the same as reading a novel. Or maybe ask for a recommendation for a really good read in a genre that's completely new to you.
Something else we were discussing elsewhere is how reading things you think you
should read can really kill the desire to read. I spent decades avoiding anything remotely resembling good-for-you reading after a period of time when I was trying to read what I thought I should read, or what people who I thought were smart recommended, and I ended up not feeling like reading at all. It was only a few months, but it affected my reading for a long time.
I've only just recently started picking up non-fiction and lit-fic again, very cautiously, making sure the recommendations come from people whose taste I tend to share, rather than people I think I should listen to. So far, so good. And I'm definitely mixing them in with fun reading.
Once reading = medicine, you might as well forget it.
