Are you new to gaming in general or just DFRPG? Have you ever GM'd before? What games have you played?
For DFRPG
- Do the City Creation phase and have your players make locations and NPC's!
- Always keep a list of Aspect (scene, character/NPC, City aspects) Use them!
- Compel a lot. It's what makes the game fun and it will get the players using their FP's more.
- Use character aspects when thinking up adventures
- Don't plan too much and let the players help guide the adventure and the story
- Be prepared: If you do city creation, this'll be easier. It's always good to have locations ready with a short list of aspects. Same with NPC's. They don't have to be fully written up - but just an outline. This is especially important if you're not the kind of person who thinks on their feet very quickly (like me).
- When that fails, Be prepared to wing it.
Unlike some rpg's DFRPG is a collaboration between the players and GM, so you should run the game with that in mind.
That's all pretty generic. Do you have any specific questions?