It all depends on what you want the friends and family and such to be.
I had a player take a stunt for his character that allowed him to replace contacts for lore, because he had a guy he could call. We named the stunt "Bobby".
If it is a recurring NPC, just give him a location and you are done. Butters could be the face for the morgue forensics department, and that would be that. If you hadn't thought him up at the beginning of the game, a player could simply declare him into existence with a fate point or roll contacts to do so. As a friend, you'd have to treat him as such. Look at DB, Harry doesn't just tell him to shut up and do as he is told, he talks to him, tells him what he wants to know about the supernatural and such. Just play out the friendship, or at least the important parts of it.
Mister would be an aspect on Harry's apartment rather than on Harry himself, since he doesn't come up all that much, I think.
Mouse can either be a PC, or you could make him an NPC that just tags along with the rest of the group. He would probably have an aspect like "I won Harry Dresden". There is actually a playable sheet for him in Our World. No Pseudo at all.
Murphy I would see similar to Butters, only she becomes a PC after a while.
Bob is a GM character, mainly for information drops (see: Talking Head). You can argue a bit back and forth, but usually, the players are going to get the information they need from him, if sometimes at a minor price.
You only need aspects for those, if you have a special bond to the characters in question, and this bond comes up in play quite often. If your character loves his mother, even though she lives 2000 miles away, that is well and good, but it will almost never come into play. On the other hand, if he is "taking care of his sick mother" she will probably come up quite often. If he is just visiting her every now and again, that's just what he does. No need for an aspect or even a character sheet, the character just has a mother, as most everyone has. Done and done.