That's exactly what I'm planning! Right down to the name.
The setting is "The Road," and there'll be generic locations (seedy motels, roadside bars), story-arc-specific locations (Creepy Gas Station, State Troopers' Station), and recurring locations (Favourite Bar, Bob's Truck Stop).
So far out of my 6 players we've got a Focused Practitioner who specializes in crafting magic items (the current plan is that one of his creations was used to break one of the Laws of Magic and that's why the Wardens are chasing them), a Minor Talent with Psychometry and Cassandra's Tears, a Changeling grifter, and a Native American who may be a Were-Form or just a Pure Mortal with really high Lore.