If you'd like to see a vampire, or other nasty-bad, with a relic akin to a Sword of the Cross, you might consider Longinus' Spear (also known as the Spear of Destiny). Seeing as how it was used to check and see if Christ was really dead, it was stained with his blood, giving it the properties of a holy relic, without the requirements to its wielder. In many a popular myth the Nazi's, or Hitler in specific, were said to have held the Spear, only starting to lose, after they lost it. (Paradoxic, neh?)
Another fun, though random tidbit: the legend of the spear is first referenced in the Gospel of... *drum roll* Nicodemus! How's that for some coincidence?