As has been said, it is all about the feel you want.
For instance, in our group only two of us have read the books, and they wanted to take advantage of that fact to run a game where they play normal people who are introduced to the world of magic: a cop, a barista, a grad student, and a newly apprentice wizard. Each of them has something in their past that is bringing supernatural attention, and together they are trying to handle the new frightening world unfolding around them. Lots of corrupt politicians and underworld bosses who have found some supernatural benefactor to give them a helping hand. As the game has gone on they uncover more and more the real behind the scenes powers at work.
So we started at 6 refresh. However, I have them on an accelerated advancement scheme: 1 adventure per in game year, 1 major milestone per adventure (an adventure takes us 3-5 sessions).
You just need to decide as a group what feel you are aiming for. Buffy the vampire is going to be a low refresh game, eventually scaling up. Dresden files is obviously going to be a high refresh game. You get a very different experience depending on how you set it up.
