I think it would be fun to post some great ideas for NPCs. I shall start with something my group came up with last night (we're composing a new campaign).
Carlos Equis, The Most Interesting Man* in the World (Yes, based on the guy in the Dos Equis commercials)
Red Court Vampire
We came up with him as the leader of the Red Court Vampires trying to take over the Brewery District in St. Louis (location aspect is "Stay Thirsty, My Friends")
*We use the term loosely.
No statblock for him, since he's just an NPC concept of course, but I don't think statblocks are really needed (they are fairly easy to do...good ideas are harder to come by).
(Maybe there's already a threat with people posting great NPC ideas as a resource, but I didn't see one on the latest two pages).