it's my understanding in the DFRPG universe that GOD's agenda is to promote free will, to allow mortals choice. the nights were formed to save the people being controlled by the denarians and the knights usually freelance anywhere there's anybody forcing people to do things against their will.
so for my game i unfortunately have 3 holy rollers and because they have somewhat differing "faiths" i have to give each a different set of rules.
my kotc knock-off gets the usual save the victim from something evil a lot, as well as some moral choices such as Imp suggested, including some of "the greater good vs. the good of the one" type.
my "holy supernatural bounty hunter" gets many kill the vampires who are trying to eat someone etc. situations as well as a few "what counts as mortal?" curveballs.
for instance: WC vampires are pretty much "Mortal" most of the time when their "inner demon" isn't in control, or is a focused practitioner still mortal even though it has supernatural powers and it's using them for evil?
my "holy human hero" aka duddly do-right wannabe gets pretty much EVERY stereotypical "But wouldn't it be good/just/fair/right/morally correct to do _____?" which has been highly entertaining since he plays his character so naive... including a RC vampire convincing him that even though it had kidnapped a party member and tortured her in it's basement that the hero COULDN'T just break into his house to take her back since that was against the law and a hero wouldn't stoop to that level