Thought I might throw out a thread where we could pop our ideas. Dresden Files games are as individual as their characters/cities, but general ideas can usually be adapted to fit anything.
Please contribute your own ideas! (That way I have something to steal as well...
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An art theft gets more than the theives bargained for when they accidentally get an important item (or Item of Power) mixed into the theft. Allows for detective work and research on the items, potential struggle with the theives, and one or more supernatural groups trying to recover/obtain the item.
Good fits: Campaigns with organized crime, virtually any supernatural threat.
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Supernatural predator that is feeding off the victim's subconscious mind. Violence on the host will merely force it to find a new victim -- to stop it, they must exorcise the creature or face it within the victim's dream-scape.
Good fits: Pretty much any campaign as a 'filler' arc or as part of a larger conspiracy.
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Displaced predators are now being forced into the city (or at least, out of the shadows) as they're moved by a larger power in their old turf. Offers a good chance to combat the immediate threat as well as seeking clues as to what upset the status quo.
Good fits: Works well with most of the supernatural predators, especially ghouls and vampires.