As far as setting goes I'm currently fixated on using Miami, just like the idea that it sets a whole different tone and has a wide variety of odd things and places (Fountain of Youth?) as well as some swamps to hide bodies...that could be re-animated of course...
And I want to use were-sharks and were-rats as well...never got to use them in any old World of Darkness games! Well not the sharks anyway. And we can in a few local celebrities; Dexter, Michael Westin and crew? Fun stuff!
You forgot about Were Alagators, in the Everglades, Immortal Cursed Pirates in on Lake Ocachobee, and the City of Rotonda, FL 33947 (check it out on google maps, its a big eight slice circular development, with one slice missing. I have decided the eighth slice is located in the Never Never).
My planed DF game will have an accorded hotel on Miami Beach, which is done in raw stone, and has an aztec style. The fence is a stone serpent and holds a "dont see me" spell that keeps the "Straights" away, allowing the more... exotic... members of the accords to come and visit without having to use personal glamor. (there are banners collecting energy from the wind, and ceramic tiled pilings in the surf collecting energy from the waves that drive the spell, rather elegant, I thought)
So far, one friend has created an Okinawan hydro-mage for his character. Am still working on finding more RL local folks I can trust to game with. Am living in the town of Davie between Ft. Laud and Miami.
Note, Was half way through thread when posted this... feel free to disregard, or delete as desired.