Yep, definite advantage. +1 Refresh worth of advantage? I really don't think so. Stuff that doesn't hurt everyone is also, as a rule, harder to get. You can't just go to the sore to pick up Holy Water like you can Cold Iron.
Also bear in mind the potential of fighting multiple enemies, some with such a Catch and some...not. A black Court Vampire with half a dozen Renfields would all be hurt by acid, only the Black Court by the Holy Water. When fighting two White Court, one each Skavis and Malvora a ring infused with True Hope is only gonna work on one of the two, and be nothing but a bauble to the Malvora.