I went to college in Savannah, so here are a few suggestions:
Be sure to use Bonaventure Cemetary, the most creepy-awesome boneyard I've ever been to. Perfect home for a powerful Black Court faction.
IMO, Red Court should be very strong there; a bastion of any Old South vampires still left over from before the Civil War. Hell, the White Court would fit here, too, for that matter. Vampires love Savannah and Savannah loves Vampires.
Government corruption is a problem there... one time when I was at school there, a hurricane was threatening to come through and the mayor ordered the entire city to be evacuated. From I have heard, that evacutation effectively prevented the mayor's political rivals from submitting their electoral paperwork in time to be on the ballot, so the mayor ran unopposed that year.
The college I went to (the Savannah College of Art & Design) is a major player in the city and they are responsible for the restoration of many, many buildings in the historic district. They get kickbacks from historical societies and governments for preserving historical buildings and do it all on-the-cheap by using the practically-free labor of their architectural students.
I'll suggest more later.