Allegedly there was a thread almost exactly like this before, but a search turned up nothing so here goes:
You know you're already thinking about your Dresden Files adventure. Maybe you've already run/played one or more. Dish! I think it'll be a good way to share ideas and just have fun. Here's one:
UntouchablePeople, particularly young and vulnerable ones, keep dying and disappearing after hanging around a famous model and actor/tress. It's suspicious enough that the police and media have asked around, but all investigations and more than one career have been dashed by the Powers That Be. Plus, cause of death is just weird and it's hard for even the most dedicated investigator to establish culpability. The player characters knew one of the dead people and/or the family, and are enlisted to find out the truth and bring the alleged perpetrator to justice.
The celebrity is a White Court vampire, of course, one that has gotten a little too arrogant about how untouchable s/he is. Problem is, it's not something the mundane authorities can really deal with. Causation is impossible to establish and the White Court has too much influence, as the stories of a washed-up cop, former district attorney, and former up-and-coming reporter who all had their careers ruined chasing this case will make abundantly clear. This influence will presently make itself known to the PCs' lives in the form of threats and smears. To mix it up a little more, the White Council doesn't want them pursuing this case because the vampire has been giving inside information to the Council when it suited his/her interests.
Resolution could take a lot of different forms. I'll probably have several different NPC's suggesting or trying to pursue different solutions. It can range from killing the holy heck out of the vamp to manipulating the White Court's political machinations to cut him/her off from its protection. Probably there will be a related plot going on that pertains to the war with the Reds.
An alternate, slightly less White Night-like possibility is to make the vamp a reformed baddie who came to see the light, but was set up to feed fatally on a mortal after working against the White and Red Courts. Now the White Court is using its influence to destroy its black (heh) sheep's reputation and life, and the Council has no more use for the vampire since the source has been compromised. Then the PC's would have to decide whether to save this repentant vampire or to let him/her go down. Perhaps in this case the vampire or a mortal parent is a friend or associate of one or more PC.
I'm really excited to start my campaign when the game comes out. In the meantime I'm just dreaming up plot seeds, and I'd like to see others', too. On a related note,
this thread about weird real-world events is a gold mine of ideas.
--Hel Lokisdottir