It has been implied that supernatural disadvantages will be handled through the use of Aspects. So a wizard might suffer technological issues as a compel against his "Reckless White Council wizard" Aspect, while a Red Court vampire would have problems going outside during the day as a Compel against her "Ancient Red Court noble" Aspect.
That should just about cover it, I'd imagine. After all, we know that the most powerful supernatural types are going to have low to non-existent Refresh. So they'll either want to give in to the compel for the fate points, or they'll actually be unable to resist at all (if at 0 or fewer Refresh).