Smaller than a Bowie knife. Not likely, unless the non-ghoul is VERY fast and strong, and even then, it would be less of a parry and more of a super-fast beating-aside of the blade... and if he's that fast and strong, that's probably the last stroke that ghoul's taking.
Now, if it were a Bowie knife, especially the larger, heavier varieties, then yes. That's pretty much a short sword, and it's very heavily, sturdily made. KA-BAR would fit the bill, too.