not my cup of tea, but I'm not an avid reader myself, and I loathe werewolf stories. Fool Moon being the exception, Jim.
Still, there's a market for anything out there, so take my opinion with a grain of salt. Personally, it sounds like you're trying to make the backstory of the character a bit too complex. A little of one, a little of another. It's a fresh angle, which is nice though. Maybe punch up the language a bit in your synopsis because it's way too much geekspeak for me. Wizards. Lycanthropes. Curses. The. Its big scary geeky words, they frighten me.
Again, there is probably a market for this, but on a mass media front of a general audience - just generalize it. Use plainer terms and simplify how you're explaining the plot and it will come off much better.